Angiotensin II Receptor Blockade: (Progress in Experimental by Naranjan S. Dhalla,Peter Zahradka,Ian M.C. Dixon,Robert E. PDF

By Naranjan S. Dhalla,Peter Zahradka,Ian M.C. Dixon,Robert E. Beamish

the connection among angiotensin II and high blood pressure used to be demonstrated in 1898 while angiotensin II used to be proven to modulate systemic blood strain. Over the intervening a long time, a whole characterization of the renin-angiotensin method (RAS) has been accomplished, and our figuring out of its biochemistry and body structure has ended in the directed improvement of brokers such ·as ACE inhibitors and receptor antagonists in a position to controlling high blood pressure. extra lately, it was once proven that angiotensin II is secreted inside of definite tissues and that those tissue-specific platforms function independently of the systemic RAS. the unconventional idea that angiotensin II regulates a few cardiovascular techniques which are unrelated to blood strain has renewed the curiosity of either simple and medical scientists in angiotensin II. The organization among angiotensin II and cardiac development, specifically, has indicated that remedies at present in use for high blood pressure can have direct program to the therapy of middle failure. The Manitoba Cardiovascular discussion board on Angiotensin Receptor Blockade in Winnipeg used to be convened October 18-20, 1996 to check the medical and easy points of angiotensin receptor biology as they follow to high blood pressure and middle failure. moreover, the capability remedy of those stipulations utilizing particular angio­ tensin receptor antagonists was once addressed in the context in their fast healing software and destiny potential.

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